SPECIALTY INTERMEDIATES

OVERVIEW

Varsal’s supplies a variety of technical intermediates that provide mission critical characteristics to a variety of specialty, niche applications. Varsal uses its technical expertise to synthesize products in order to help its customers solve their most complex issues!

trans-Cyclobutane-1,2-dicarboxylic acid

  • Other names: trans-1,2-Cyclobutanedicarboxylic acid
  • Molecular weight: 144.13
  • Appearance: colorless crystals
  • CAS#: 1124-13-6

Used as a specialty intermediate for various reasons, including as a diacid monomer or cross-linker for producing thermoplastics and thermosets.

  • Electronics
  • Pharmaceutical
  • Industrial

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-[2-(Methacryloyloxy)ethyloxy]ethyl isocyanate

  • Other names: 2-(2-Isocyanatoethoxy)ethyl methacrylate
  • Molecular weight: 199.20
  • Appearance: colorless to yellow liquid
  • CAS#: 107023-60-9

Used as a specialty intermediate for a variety of reasons due to its attractive qualities as a dual functional monomer with various attractive groups.

It is used as an intermediate to produce urethane methacrylates, as it shows higher reactivity towards polyols compared to traditional aliphatic isocyanates.  Thus, the formed urethane methacrylates exhibit high reactivity and sensitivity.

It is also able to be used as an intermediate to produce acrylic isocyanate copolymers. The formed products is stable to free radicals, so it is able to react in the presence of peroxides or azo compounds.

 

  • Specialty Packaging
  • Electronics
  • Pharmaceutical
  • Industrial

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-Isocyanatoethyl methacrylate

  • Other names:  2-(Methacryloyloxy)ethyl isocyanate
  • Molecular weight: 155.15
  • Appearance: colorless to yellow liquid
  • CAS#: 30674-80-7

Used as a specialty intermediate for a variety of reasons, including as a cross-linker for resins and coatings.

 

  • Specialty Packaging
  • Electronics
  • Pharmaceutical
  • Industrial

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

3,5-Dichloro-2,4,6-trifluoropyridine

  • Other names:  3,5-Dichloro-2,4,6-trifluoropyridin
  • Molecular weight: 201.96
  • Appearance: colorless liquid
  • CAS#: 1737-93-5

Used as a specialty intermediate for a variety of reasons, including in the preparation of affinity gels used in the purification of immunoglobulin G.

 

  • Pharmaceutical
  • Agricultural

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

Bis[4-(hexyloxy)phenyl]methanone

  • Other names:  N/A
  • Molecular weight: 382.54
  • Appearance: white solid
  • CAS#: 1108157-34-1

Used as a specialty intermediate for a variety of reasons, including in crosslinked polyolefins formed from extruded polyolefins containing photoinitiators.

 

  • Specialty Industrial

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

Cyclobutanemethanol

  • Other names:  (Hydroxymethyl)cyclobutane
  • Molecular weight: 86.13
  • Appearance: colorless to near colorless clear liquid
  • CAS#: 4415-82-1

Used in a variety of applications, including in the synthesis of bicyclic lactones. Lactones are in many natural products used in the flavors and fragrances industry, and also exhibit attractive antioxidant, antimicrobial, and anticancer properties.

 

  • Flavors and Fragrances
  • Food and Beverage
  • Plastics
  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

2,6-Dimethoxyphenylboronic acid

  • Other names:  N/A
  • Molecular weight: 181.98
  • Appearance: white to near white crystalline powder
  • CAS#: 23112-96-1

Used in a variety of applications, including as a reagent in the palladium-catalyzed Suzuki-Miyaura coupling reaction to construct carbon-carbon bond, in the synthesis of 2H-imidazo[1,5-a]pyridin-4-ium bromides, which are utilized as precursors for the preparation of N-heterocyclic carbene ligands, and in the preparation of monosubstituted benzothiazoloquinazolinones as potential monoamine oxidases inhibitors.

Additionally, it is a common reactant in the Suzuki-Miyaura reactions, which have widespread usage in the synthesis of pharmaceutical intermediates, fine chemicals, and other complex compounds.

 

  • Industrial
  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

2-Amino-5-methoxypyridine

  • Other names:  5-Methoxypyridin-2-amine
  • Molecular weight: 124.14
  • Appearance: colorless to light orange liquid
  • CAS#: 10167-97-2

Used in a variety of organic synthesis applications, including for the manufacture of Avosentan (used in diabetic nephropathy), Pirfenidone (anti-inflammatory, anti-oxidant and antifibrotic agent) and Zolpidem (sedative/ hypnotics). It is also used for the manufacture of the pesticide Fluazuron.

 

  • Agricultural
  • Industrial
  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

2-Tolylboronic acid

  • Other names:  N/A
  • Molecular weight: 135.96
  • Appearance: white to beige crystalline powder
  • CAS#: 16419-60-6

Used as a reagent in a variety of applications, including:

 

  • Palladium-catalyzed direct arylation of pyrazoles with phenylboronic acids
  • Pd-catalyzed arylation using Suzuki-Miyaura cross-coupling in water
  • Ruthenium catalyzed direct arylation reactions
  • Ligand-free copper-catalyzed coupling reactions
  • Copper-catalyzed cross-coupling reactions of diaryl diselenides
  • Phosphine-free Suzuki-Miyaura cross-coupling reactions
  • Rhodium-catalyzed asymmetric 1,4-addition reactions
  • Chiral monophosphorus ligands in asymmetric Suzuki-Miyaura coupling reaction
  • Palladium nanoparticles immobilized by click ionic copolymers as recyclable catalysts for Suzuki-Miyaura cross-coupling reaction in water
  • Human farnesyl pyrophosphate synthase inhibitors as antitumor agents for multiple myeloma cells 
  • Industrial
  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

4-CYANO-3-FLUOROPHENYLBORONIC ACID

  • Other names:  N/A
  • Molecular weight: 164.93
  • Appearance: white to near white crystalline powder
  • CAS#: 843663-18-3

Used in a variety of applications, including in the Suzuki-Miyaura reactions, which have widespread usage in the synthesis of pharmaceutical intermediates, fine chemicals, and other complex compounds.

    • Industrial
    • Pharmaceutical

    Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

    2-(5-Methoxypyridin-2-yl)acetic acid

    • Other names:  N/A
    • Molecular weight: 167.16
    • Appearance: white to brown powder
    • CAS#: 1214332-39-4

    Used as an intermediate in a variety of applications.

      • Industrial
      • Pharmaceutical

      Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

      Formamidine acetate

      • Other names:  N/A
      • Molecular weight: 104.11
      • Appearance: colorless to yellowish crystalline powder
      • CAS#: 3473-63-0

      Used in a variety of applications, including in the synthesis of active pharmaceutical ingredients and as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.

      • Agricultural
      • Industrial
      • Pharmaceutical

      Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

      4-Hydroxy-2-butanone

      • Other names:  2-Hydroxyethyl Methyl Ketone
      • Molecular weight: 88.11
      • Appearance: colorless to pale yellow liquid
      • CAS#: 590-90-9

      Used as an intermediate in a variety of applications, including:

       

      • Fused benzazepine molecules as selective D3 receptor antagonists
      • Verrucarin and mevalonic acid lactone
      • 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst
      • 4-methyl-5-hydroxymethylthiazole, lineatin, beta-hydroxylactones
      • Agricultural
      • Industrial
      • Pharmaceutical

      Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

      R-N,N-Dimethyl-1-ferrocenylethylamine

      • Other names:  N/A
      • Molecular weight: 257.15
      • Appearance: clear to orange liquid
      • CAS#: 31886-58-5

      Used as a starting material in a variety of processes, including in chiral 1,2-disubstituted ferrocenyl amino alcohols, ferrocene-based P-chiral phosphine ligands, and optically active α-ferrocenyl tertiary amines. It is also a ligand used in the preparation of chiral allylic alcohols, axially chiral allenecarboxylic esters, and rhodium(I)-catalyzed asymmetric hydrosilylation of ketones.

        • Food and Beverage
        • Industrial
        • Pharmaceutical

        Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

        (S)-N,N-Dimethyl-1-ferrocenylethylamine

        • Other names:  N/A
        • Molecular weight: 257.15
        • Appearance: clear to yellow liquid
        • CAS#: 31886-57-4

        Used in a variety of applications, including as a starting material in the synthesis of chiral diferrocenylphosphine-diamines applicable in catalysis, and as a model chiral probe in the study of enantiodiscrimination ability of chiral ionic liquids using cyclic voltammetry.

          • Industrial
          • Pharmaceutical

          Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers. 

          Varsal is a technically focused, high-quality ISO | GMP compliant specialty chemicals and pharmaceutical intermediates.  

          By continuously investing in our product portfolio and researching new solutions that benefit our stakeholders, the environment and society, we seeks to build long-lasting partnerships by helping to solve its customer most complex issues through customized, quality product solutions.

          We welcome all inquiries to help with product inquiries, testing, product evaluation or applications research, please contact us to learn more how we can help solve your complex chemical and intermediate needs!

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