SPECIALTY INTERMEDIATES
OVERVIEW
Varsal supplies a variety of technical intermediates that provide mission critical characteristics for a variety of specialty, niche applications. Varsal uses its technical expertise to synthesize products in order to help our customers solve their most complex issues!
trans-Cyclobutane-1,2-dicarboxylic acid
- Other names: trans-1,2-Cyclobutanedicarboxylic acid
- Molecular weight: 144.13
- Appearance: colorless crystals
- CAS#: 1124-13-6
Used as a specialty intermediate for various reasons, including as a diacid monomer or cross-linker for producing thermoplastics and thermosets.
- Electronics
- Pharmaceutical
- Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2-[2-(Methacryloyloxy)ethyloxy]ethyl isocyanate
- Other names: 2-(2-Isocyanatoethoxy)ethyl methacrylate, Product M
- Molecular weight: 199.20
- Appearance: colorless to yellow liquid
- CAS#: 107023-60-9
Used as a specialty material for a variety of reasons due to its attractive qualities as a dual-functional monomer.
Varsal’s Product M is used to produce urethane methacrylates, as it shows higher reactivity towards polyols compared to traditional aliphatic isocyanates. Thus, the formed urethane methacrylates exhibit high reactivity and sensitivity.
It can also be used to produce acrylic isocyanate copolymers. The formed products are stable to free radicals, so they are able to react in the presence of peroxides or azo compounds.
- Specialty Packaging
- Electronics
- Pharmaceutical
- Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2-Isocyanatoethyl methacrylate (IEM)
- Other names: 2-(Methacryloyloxy)ethyl isocyanate
- Molecular weight: 155.15
- Appearance: colorless to yellow liquid
- CAS#: 30674-80-7
Used as a specialty intermediate for a variety of reasons, including as a cross-linker for resins and coatings.
- Specialty Packaging
- Electronics
- Pharmaceutical
- Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
3-(TRIFLUOROMETHYL)-1H-PYRAZOLE
- Other names: 3-(trifluoromethyl)pyrazole, 3-trifluoromethyl-1H-pyrazole, 3-trifluoromethylpyrazole
- Molecular weight: 136.08
- Appearance: white to off-white crystalline powder
- CAS#: 20154-03-4
Used as a specialty intermediate (building block) for various reasons, such as synthesis of ligands for OLEDs.
- Agricultural
- Pharmaceutical
- Electronics
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
3,5-Dichloro-2,4,6-trifluoropyridine
- Other names: 3,5-Dichloro-2,4,6-trifluoropyridin
- Molecular weight: 201.96
- Appearance: colorless liquid
- CAS#: 1737-93-5
Used as a specialty intermediate for a variety of reasons, including in the preparation of affinity gels used in the purification of immunoglobulin G.
- Pharmaceutical
- Agricultural
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Bis[4-(hexyloxy)phenyl]methanone
- Other names: 4,4′-Bis(hexyloxy)benzophenone
- Molecular weight: 382.54
- Appearance: white solid
- CAS#: 1108157-34-1
Used as a specialty material for various reasons, including as a photoinitiator in crosslinking extruded polyolefins.
- Specialty Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Cyclobutanemethanol
- Other names: (Hydroxymethyl)cyclobutane, Cyclobutylmethanol
- Molecular weight: 86.13
- Appearance: colorless to near colorless clear liquid
- CAS#: 4415-82-1
Used in a variety of applications, including in the synthesis of bicyclic lactones. Lactones are in many natural products used in the flavors and fragrances industry, and also exhibit attractive antioxidant, antimicrobial, and anticancer properties.
- Flavors and Fragrances
- Food and Beverage
- Plastics
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2,6-Dimethoxyphenylboronic acid
- Other names: 2,6-Dimethoxybenzeneboronic acid
- Molecular weight: 181.98
- Appearance: white to near white crystalline powder
- CAS#: 23112-96-1
Used in a variety of applications, including as a reagent in the Pd-catalyzed Suzuki-Miyaura coupling reaction to construct a carbon-carbon bond; in the synthesis of 2H-imidazo[1,5-a]pyridin-4-ium bromides, which are precursors in the preparation of N-heterocyclic carbene ligands; and, in the preparation of monosubstituted benzothiazoloquinazolinones as potential monoamine oxidases inhibitors.
Additionally, it is a common reactant in Suzuki-Miyaura reactions, which have widespread usage in the synthesis of pharmaceutical intermediates, fine chemicals, and other complex compounds.
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2-Amino-5-methoxypyridine
- Other names: 5-Methoxypyridin-2-amine
- Molecular weight: 124.14
- Appearance: colorless to light orange liquid
- CAS#: 10167-97-2
Used in a variety of applications, including C. difficile toxin inhibitor synthesis.
- Agricultural
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2-Tolylboronic acid
- Other names: 2-Methylphenylboronic acid, o-Tolylboronic acid
- Molecular weight: 135.96
- Appearance: white to beige crystalline powder
- CAS#: 16419-60-6
Used as a reagent in a variety of applications, including:
- Palladium-catalyzed direct arylation of pyrazoles with phenylboronic acids
- Pd-catalyzed arylation using Suzuki-Miyaura cross-coupling in water
- Ruthenium catalyzed direct arylation reactions
- Ligand-free copper-catalyzed coupling reactions
- Copper-catalyzed cross-coupling reactions of diaryl diselenides
- Phosphine-free Suzuki-Miyaura cross-coupling reactions
- Rhodium-catalyzed asymmetric 1,4-addition reactions
- Chiral monophosphorus ligands in asymmetric Suzuki-Miyaura coupling reaction
- Palladium nanoparticles immobilized by click ionic copolymers as recyclable catalysts for Suzuki-Miyaura cross-coupling reaction in water
- Human farnesyl pyrophosphate synthase inhibitors as antitumor agents for multiple myeloma cells
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
4-CYANO-3-FLUOROPHENYLBORONIC ACID
- Other names: 4-Cyano-3-fluorobenzeneboronic acid
- Molecular weight: 164.93
- Appearance: white to near white crystalline powder
- CAS#: 843663-18-3
Used in a variety of applications, including in the Suzuki-Miyaura reactions, which have widespread usage in the synthesis of pharmaceutical intermediates, fine chemicals, and other complex compounds.
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
2-(5-Methoxypyridin-2-yl)acetic acid
- Other names: N/A
- Molecular weight: 167.16
- Appearance: white to brown powder
- CAS#: 1214332-39-4
Used as an intermediate in a variety of applications.
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Formamidine acetate
- Other names: Methanimidamide Monoacetate
- Molecular weight: 104.11
- Appearance: colorless to yellowish crystalline powder
- CAS#: 3473-63-0
Used in a variety of applications, including in the synthesis of active pharmaceutical ingredients and as a condensing agent for the preparation of pyrimidine and imidazole heterocycles.
- Agricultural
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
4-Hydroxy-2-butanone
- Other names: 2-Hydroxyethyl methyl ketone, 4-Hydroxybutan-2-one
- Molecular weight: 88.11
- Appearance: colorless to pale yellow liquid
- CAS#: 590-90-9
Used as an intermediate in a variety of applications, including the synthesis of:
- Fused benzazepine molecules as selective D3 receptor antagonists
- Verrucarin and mevalonic acid lactone
- 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst
- 4-methyl-5-hydroxymethylthiazole, lineatin, beta-hydroxylactones
- Agricultural
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
(R)-N,N-Dimethyl-1-ferrocenylethylamine
- Other names: N/A
- Molecular weight: 257.15
- Appearance: clear to orange liquid
- CAS#: 31886-58-5
Used as a starting material in a variety of processes, including synthesis of chiral 1,2-disubstituted ferrocenyl amino alcohols, ferrocene-based P-chiral phosphine ligands, and optically active α-ferrocenyl tertiary amines. It is also a ligand used in the preparation of chiral allylic alcohols, axially chiral allenecarboxylic esters, and the rhodium(I)-catalyzed asymmetric hydrosilylation of ketones.
- Food and Beverage
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
(S)-N,N-Dimethyl-1-ferrocenylethylamine
- Other names: N/A
- Molecular weight: 257.15
- Appearance: clear to yellow liquid
- CAS#: 31886-57-4
Used as a starting material in the synthesis of chiral diferrocenylphosphine-diamines applicable to catalysis, and as a model chiral probe in the study of enantiodiscrimination ability of chiral ionic liquids using cyclic voltammetry.
- Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
7-Bromo-1-heptene
- Other names: 6-heptenyl bromide, 7-bromohept-1-ene
- Molecular weight: 177.08
- Appearance: colorless liquid
- CAS#: 4117-09-3
7-Bromo-1-heptene is a linear halogenated alkene commonly used as an alkylating agent. This material may be used to synthesize a range of compounds, including:
- 9-hept-6-enyloxy-5-hydroxymethyl-2-isopropyl-1-methyl-1,4,5,6-tetrahydro-2H-benzo[e][1,4] diazocin-3-one
- boc-L-2-amino-8-nonenoic acid
- 8-hydroxy-15,15,15-trifluoro-1-pentadece
It is also used as a reagent in the synthesis of (R)-(+)-Lasiodiplodin, a macrolide that exhibits potent antileukemic activity against human tumors.
- Specialty Industrial
- Chemical
- Pharmaceutical
- Oil & Gas
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
8-Bromo-1-octene
- Other names: 7-octenyl bromide, 8-bromooct-1-ene
- Molecular weight: 191.11
- Appearance: clear to light yellow liquid
- CAS#: 2695-48-9
8-Bromo-1-octene has been used in preparation of polymerizable ligands, required for the synthesis of quantum dot-labeled polymer beads. A Grignard reagent derived from 8-bromo-1-octene has been used in the synthesis of (2S,3S,5R)-5-[(1R)-1-hydroxy-9-decenyl]-2-pentyltetrahydro-3-furanol.
It has been used as a building block in natural product synthesis, as well as in the synthesis of more complex pharmaceutical compounds, such as Dithienogermole derivatives with varying alkyl chain lengths and pendant functionalities.
- Specialty Industrial
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
9-Bromo-1-nonene
- Other names: 8-nonenyl bromide, 9-bromonon-1-ene
- Molecular weight: 205.14
- Appearance: clear to pale yellow liquid
- CAS#: 89359-54-6
9-Bromo-1-nonene is used as a key intermediate in organic synthesis, agrochemical, pharmaceutical and dyestuff applications.
- Specialty Industrial
- Agricultural
- Pharmaceutical
- Textiles
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
10-Bromo-1-decene
- Other names: 9-decenyl bromide; 10-bromodec-1-ene
- Molecular weight: 219.16
- Appearance: colorless liquid
- CAS#: 62871-09-4
10-Bromo-1-decene is a key starting material for production of 1-decene, an alpha olefin used in a variety of applications. Such uses include serving as a comonomer, and as an intermediate in production of epoxides, amines, oxo alcohols, synthetic lubricants, synthetic fatty acids and alkylated aromatics.
10-Bromo-1-decene may also be used to synthesize:
- 4′-(9-decenyloxy)biphenyl-4-carboxylic acid methyl ester
- 4′-(9-decenyloxy)biphenyl-4-carboxylic acid
- 9-decenylmagnesium bromide
- Specialty Industrial
- Chemical
- Pharmaceutical
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
11-Bromo-1-Undecene
- Other names: 10-undecenyl bromide, 11-Bromoundec-1-ene
- Molecular weight: 233.19
- Appearance: clear, colorless to near colorless liquid
- CAS#: 7766-50-9
11-Bromo-1-undecene is a halogenated hydrocarbon with a wide variety of uses in advanced polymer dielectrics.
- Specialty Industrial
- Electronics
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
3-Bromopentane
- Other names: 3-Pentyl bromide
- Molecular weight: 151.04
- Appearance: clear to pale yellow liquid
- CAS#: 1809-10-5
3-Bromopentane is a glass forming liquid used in various chemical synthesis applications, including in the preparation of 2-(1-ethyl-propoxy)-isoindole-1,3-dione, and in the process of cobalt-catalyzed ortho alkylation of aromatic imines
- Specialty Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
8-chloro-1-octene
- Other names: 8-chlorooct-1-ene
- Molecular weight: 146.66
- Appearance: clear, colorless liquid
- CAS#: 871-90-9
8-chloro-1-octene comonomer is useful as an additive in the production of polymers of Ziegler hydrocarbons (e.g., polyethylene, polypropylene, poly-4-methyl-1-pentene). Incorporating a small amount of this compound increases the polymer’s suitability for dyeing and vulcanization.
8-chloro-1-octene has also been used in the preparation of modified polymers with aromatic groups, and may be used for alkene halogenation in the manufacture of heat-resistant polylactic acid extrusion foams. Another use of this chloroalkene is in the production of silane compounds that contain a mercapto group.
- Specialty Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.
Cyclopentyl methyl ether (CPME)
- Other names: N/A
- Molecular weight: 100.16
- Appearance: clear, colorless liquid
- CAS#: 5614-37-9
CPME is used in a variety of applications, including Grignard Reaction, Suzuki Coupling, Buchwald Amination, Metal Reductions (NaBH4, LiAlH4, i-Bu2AlH), Reactions with n-BuLi, Reactions with Lewis Acid, Friedel Crafts Reactions. It is also used in extractions, crystallizations, polymerizations and coatings.
- Pharmaceutical
- Specialty Industrial
Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.