Pharmaceutical Intermediates

PharmIntermediats

OVERVIEW

Varsal has extensive technical capabilities in developing and manufacturing sophisticated Pharmaceutical Intermediates at our GMP-compliant facilities. We also custom manufacture other Pharmaceutical upon request—please contact us for more information!

Toluenesulfonylmethyl Isocyanide (TosMIC)

  • Other names: p-Toluenesulfonylmethylisocyanide, TosMIC
  • Molecular weight: 195.24
  • Appearance: colorless crystalline powder, off-white to yellowish
  • CAS#: 36635-61-7

 

Used as an intermediate for various reasons, including in the Van Leusen reaction which is used to convert aldehydes to nitriles or in the preparation of oxazoles and imidazoles.

Three of TosMIC’s mission-critical industrial applications are:

  1. To convert carbonyl groups to nitriles as a cyanating reagent
  2. To synthesize heterocyclic compounds such as oxazoles, imidazoles and pyrroles
  3. To prepare Knoevenagel-type condensation products

  • Pharmaceutical
  • Agriculture
  • Food
  • Electronics

Varsal is one of the world’s leading producers of TosMIC, and one of the few producers capable of producing large-scale, pharma-grade material. Varsal’s proprietary manufacturing and treatment process allows it to produce extremely high purity material with low residual impurities, low loss on drying, and low residue on ignition, leading to maximal yield and product quality for Varsal’s customers.

N,N’-dicyclohexylcarbodiimide (DCC)

  • Other names: DCC
  • Molecular weight: 206.33
  • Appearance: white to slight yellow crystalline solid
  • CAS#: 538-75-0

Used as an intermediate for various reasons, including to couple amino acids during artificial peptide synthesis.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.

Acetamidine Hydrochloride

  • Other names: ethanimidamide, ethanamidine acetimidamide, carboxamidine, carboximidamide
  • Molecular weight: 94.54
  • Appearance: white or yellowish long prismatic crystals
  • CAS#: 124-42-5

Used as a Vitamin B1 building block, strong non-ionic nucleophile, intermediate in antihypertensive APIs, guanidine derivative.

  • Pharmaceutical
  • Personal Care
  • Industrial

Varsal leverages its deep chlorination and technical manufacturing resources to produce material that has extremely high purity with low residual impurities, low moisture and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.

3-oxo-2-phenylbutanamide

  • Other names: 2-phenyl-acetoacetic acid amide, 2-phenyl-acetessigsaeure-amid, 2-phenyl-3-oxobutanamide
  • Molecular weight: 177.20
  • Appearance: white powder
  • CAS#: 4433-77-6

Used as a pharmaceutical intermediate.

  • Pharmaceutical

Varsal leverages its deep technical manufacturing resources to produce material that has extremely high purity with low residual impurities, low moisture and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.

Mechlorethamine Hydrochloride

  • Other names: chloramine
  • Molecular weight: 192.52
  • Appearance: white crystalline powder
  • CAS#: 55-86-7

API in anti-tumor drugs (DNA alkylation of guanines), psoriasis, vitiligo, mycosis fungoides, can also be used as an immunosuppressant.

  • Pharmaceutical

Varsal leverages its deep chlorination and technical manufacturing resources to produce material that has extremely high purity with low residual impurities, low moisture, low residue on ignition and low loss on drying, leading to maximal yield and product quality for Varsal’s customers.

Trifluorotoluene

  • Other names: Benzotrifluoride (BTF), α,α,α-Trifluorotoluene
  • Molecular weight: 146.11
  • Appearance: clear, colorless liquid
  • CAS#: 98-08-8

Used as a specialty solvent in organic synthesis and an intermediate in the production of pesticides and pharmaceuticals.

  • Pharmaceutical
  • Agriculture

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2,6-Dibromopyridine

  • Other names: 2,6-dibromo
  • Molecular weight: 236.89
  • Appearance: light brown to white crystals
  • CAS#: 626-05-1

Used as an intermediate for a variety of applications, including as a tridentate chelating ligand and in macrocycle formation contained in the terpyridine moiety. It is also used to produce 6-bromo-2-methoxypyridine.

  • Pharmaceutical
  • Specialty Industrial

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

5-(2R)-2-Oxiranyl-8-benzyloxy-2(1H)-quinolinone

  • Other names: indacaterol intermediate 
  • Molecular weight: 293.32
  • Appearance: white to light yellow crystalline powder
  • CAS#: 173140-90-4

Used in a variety of applications, including as an indacaterol intermediate used in the preparation of hydroxyquinoline substituted aminoindans as β2-adrenoceptor agonists with potentials as ultralong-acting bronchodilators.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Benzyl Indacaterol

  • Other names: (R)-8-(Benzyloxy)-5-[2-(5,6-diethylindan-2-ylamino)-1-hydroxyethyl]-1H-quinolin-2-one, Indacaterol Intermediate
  • Molecular weight: 482.61
  • Appearance: white to light yellow crystalline powder
  • CAS#: 435273-75-9

Used in a variety of applications, including as a reactant in the preparation of Indacaterol (I499745)—a β-adrenoreceptor agonist.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Carfilzomib Intermediate

  • Other names: benzyl ((S)-2-((tert-butoxycarbonyl)amino)-4-phenylbutanoyl)-L-leucyl-L-phenylalaninate
  • Molecular weight: 629.79
  • Appearance: white or off-white powder
  • CAS#: 868540-15-2

Used in a variety of applications, including as a reactant in the preparation of Carfilzomib— an anti-cancer medication and selective proteasome inhibitor.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

Cyclobutylmethylamine hydrochloride

  • Other names: N/A
  • Molecular weight: 121.61
  • Appearance: off-white to pale brown solid
  • CAS#: 5454-82-0

Used in a variety of applications, including as a reactant in the preparation of cyclobutylarachidonylamide.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2-HYDROXY-6-METHOXYBENZALDEHYDE

  • Other names: N/A
  • Molecular weight: 152.15
  • Appearance: pale yellow to pale brown powder
  • CAS#: 700-44-7

Used in a variety of applications, including as a pharmaceutical intermediate.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

2,6-Dimethoxybenzaldehyde

  • Other names: N/A
  • Molecular weight: 166.17
  • Appearance: white to green crystalline powder
  • CAS#: 3392-97-0

Used in a variety of applications, including in the preparation of 2,6-dihydroxybenzaldehyde by demethylation with AlBr3.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

4-[1-(4,5-DIHYDRO-4,4-DIMETHYL-2-OXAZOLYL)-1-METHYLETHYL]-BENZENEETHANOL

  • Other names: N/A
  • Molecular weight: 261.36
  • Appearance: white to off-white powder
  • CAS#: 361382-26-5

Used in a variety of applications, including in the production of Bilastine—a second-generation antihistamine medication used to treat allergic rhinoconjunctivitis and urticaria.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

O-(2-(vinyloxy)ethyl)hydroxylamine

  • Other names: N/A
  • Molecular weight: 103.12
  • Appearance: colorless to yellow liquid
  • CAS#: 391212-29-6

Used in a variety of applications, including in the synthesis of various heterocyclic compounds as mitogen-activated protein kinase MEK inhibitors (i.e. Binimetinib).

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

(R)-3-Amino-1-butanol

  • Other names: N/A
  • Molecular weight: 89.14
  • Appearance: colorless to yellow liquid
  • CAS#: 61477-40-5

Used in a variety of applications, including as a key intermediate of the HIV/AIDS treatment medication Dolutegravir. Its green and efficient biosynthesis makes it an attractive candidate for a large range of applications.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

6-Chloro-1-hexene

  • Other names: N/A
  • Molecular weight: 118.6
  • Appearance: colorless to yellow liquid
  • CAS#: 928-89-2

6-Chloro-1-hexene is an ω-chloro-1-alkene, and is mainly used as a pharmaceutical intermediate, including in the synthesis of 1-(5-hexen)-2,3-dimethyl-imidazolium chloride. It reacts with β-substituted imines in the presence of a rhodium catalyst to afford tri- and tetra-substituted imines, and undergoes cross-coupling reaction in the presence of copper(II) chloride and 1-phenylpropyne.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

7-Chloro-1-heptene

  • Other names: 7-Chlorohept-1-ene
  • Molecular weight: 132.63
  • Appearance: colorless to pale yellow liquid
  • CAS#: 929-21-5

7-Chloro-1-heptene is used as a pharmaceutical intermediate in a variety of applications.

  • Pharmaceutical

Varsal’s material has extremely high purity with low residual impurities, leading to maximal yield and product quality for Varsal’s customers.

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